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California’s game against Southern California was postponed on Tuesday after a series of positive coronavirus tests in the Golden Bears program, the first major college football game to be rescheduled this season because of COVID-19.

Cal played last week at Arizona without starting quarterback Chase Garbers and six other starters because of positive tests that knocked out 24 players and assistant coaches. The Bears lost 10-3 to Arizona.

Cal announced Tuesday that additional players tested positive this week and are unavailable to practice or play, leading to the postponement. Athletic director Jim Knowlton called it a “difficult decision.”

“We know how important every one of our games is to our student-athletes, especially our seniors who have been incredible representatives of the program, but it was the right thing to do,” Knowlton said. “Due to additional impact on specific position groups, we have decided to postpone Saturday’s game. We have had multiple COVID-19 positives within our program, and we are taking every step we can to mitigate the spread and protect the greater community.”

The schools have agreed to rescheduled the game for Dec. 4, the day after the Pac-12 title game.

Coach Justin Wilcox said he was upset for the fans and the players but added there was no choice.

“It’s been in Ohio as early as the mid-1850s at least, brought in as an ornamental plant because of its unique foliage and white flowers,” Gardner said. “It was actually planted in people’s landscaping, and it has been spreading.”

“Postponing this game was a last resort and not an action any of us wanted to take; however, it was not possible for us to field a team on Saturday,” Wilcox said.

Garbers criticized school and Berkeley city officials in a Twitter post Monday night, saying they had not been transparent over whether COVID-19 tests for vaccinated players are recommended or mandated. Cal said 99% of its players are vaccinated but several have tested positive anyway and are required by the city to isolate for 10 days regardless of vaccination status.

“We have worked too hard to have someone take this all away from us. It is wrong,” Garbers wrote. “We deserve answers and transparent communication.”