Republican senators blocked a bill Monday night to keep the government operating and allow federal borrowing, but Democrats aiming to avert a shutdown pledged to try again — at the same time pressing ahead on President Joe Biden’s big plans to reshape government.

The efforts are not necessarily linked, but the fiscal yearend deadline to fund the government past Thursday is bumping up against the Democrats’ desire to make progress on Biden’s expansive $3.5 trillion federal overhaul.

It’s all making for a tumultuous moment for Biden and his party, with consequences certain to shape his presidency and the lawmakers’ own political futures.

Success would mean a landmark accomplishment, if Democrats can helm Biden’s big bill to passage. Failure — or a highly unlikely government shutdown and debt crisis — could derail careers.

“You know me, I’m a born optimist,” Biden told reporters Monday, as he rolled up his sleeve for a COVID-19 booster shot. “We’re gonna get it done.”

Monday’s 50-48 vote against taking up the bill fell well short of the 60 needed to proceed over a GOP filibuster. Democratic Majority Leader Chuck Schumer switched his vote to “no,” a procedural step to allow him to bring the measure back for consideration, which he said would happen this week.

With days to go, Democrats said they will try again before Thursday’s deadline to pass a bill funding government operations past the Sept. 30 fiscal yearend, stripping out the debate over the debt limit for another day, closer to a separate October deadline.

Meanwhile, the real action is unfolding behind the scenes over the $3.5 trillion measure, with Biden and his Democratic allies in Congress seeking a once-in-a-generation reworking of the nation’s balance sheets.

From free pre-kindergarten and child care subsidies for families with small children to dental care and hearing aids for seniors with Medicare, there’s a lot in the president’s proposal — all to be paid for with higher taxes on corporations and the wealthy.

With Republicans solidly opposed, Democrats are rushing to trim the total and win holdouts within their own party.

“We just have to make difficult choices,” Speaker Nancy Pelosi told House Democrats during an evening caucus meeting, according to a person granted anonymity to discuss the private session.

As the overall price tag comes down, Pelosi said the president is “working on that piece,” referring to talks underway with the Senate. Despite the rush to amass votes, Pelosi said the House Democrats would not move ahead on a bill until it is acceptable to their colleagues in the Senate. “We’re not there yet,” she said.

Exiting the caucus meeting, Rep. Richard Neal, D-Mass., the chairman of the Way & Means Committee, said as momentum builds toward Thursday, he was expecting a new total amount: “Let’s pop the number.”

Building on a separate $1 trillion bipartisan public works package that’s already cleared the Senate and is heading for a House vote, also Thursday, Biden is seeking major spending for health care, education and efforts to tackle climate change. The total price tag, he contends, is actually “zero” — covered by the expected increase in tax revenue.

He is personally calling fellow Democrats in Congress an effort to resolve differences and bring his sweeping domestic policy vision forward.

Ticking off the weighty list of goals along with meeting the other deadlines, Biden said, “If we do that, the country’s going to be in great shape.”

Biden, Pelosi and Schumer conferred in the afternoon on the path forward and will “continue their close coordination over the coming days,” the White House said in a readout of the call.

But Republicans say it’s real spending that can’t be afforded, and a reflection of the Democrats’ drive to insert government into people’s lives.

And so far, the bill is also too big for key Democrats whose votes are needed in the face of the GOP opposition. Two Democratic holdouts, Sens. Joe Manchin of West Virginia and Kyrsten Sinema of Arizona, have said they won’t support a bill of that size. Manchin has previously proposed spending of $1 trillion to $1.5 trillion.

Progressive lawmakers said they’ve already compromised enough with more centrist Democrats, but in one potential development, Rep. Pramila Jayapal, D-Wash., the chair of the Congressional Progressive Caucus, confirmed she and Sinema have been in talks.

With all Republicans opposed, Democratic leaders can’t spare a single vote in the 50-50 Senate, relying on Vice President Kamala Harris to break a tie to pass the eventual package.

All this comes as other deadlines swirl this week to pay for government operations and allow more borrowing or risk a devastating federal shutdown or debt default — though those dire scenarios appear unlikely.

The bill Senate Republicans rejected Monday night would have funded government operations temporarily, to early December, while also providing emergency funds for Hurricane Ida and other disaster relief and for Afghan refugees.

Republican leader Mitch McConnell rejected that approach because Democrats also included a provision to suspend the debt limit, which would allow continued borrowing to pay off the nation’s bills.

Once a routine matter, raising the debt limit is now a political weapon of choice wielded by Republicans to attack Democrats — even though both parties have been responsible for piling on debt.

“The Democrats will do the responsible thing — the right thing, the thing that has been done for decades by both parties — and vote yes,” said Schumer ahead of the vote.

He called the Republican opposition “unhinged.”

McConnell has said he wants to fund the government and prevent a devastating debt default, but wants to force Democrats to split the package in two and take the politically uncomfortable debt ceiling vote on their own.

“Republicans are not rooting for a shutdown or a debt limit breach,” he said.

The House began debating the public works bill late Monday, and while it won bipartisan support in the Senate, House Republican leaders are wary of supporting it. Donald Trump, the former president who tried and failed to secure an infrastructure deal when he was in the White House, is rallying opposition to it.

As Pelosi huddled privately Monday with House Democrats, it was clear she is pressing ahead to move as swiftly as possible on Biden’s broader package.

Biden’s proposal is to be paid for by increasing the corporate tax rate, from 21% to 26.5% on businesses earning more than $5 million a year, and raising the top rate on individuals from 37% to 39.6% for those earning more than $400,000 a year, or $450,000 for couples.

While Democrats are largely in agreement on Biden’s vision — many ran their campaigns on the longstanding party priorities — stubborn disputes remain, including how to push toward cleaner energy or to lower prescription drug costs.