With masks, ventilators and political goodwill in desperately short supply, more than one-fifth of the world’s population was ordered or urged to stay in their homes Monday at the start of what could be a pivotal week in the battle to contain the coronavirus in the U.S. and Europe.

Partisan divisions stalled efforts to pass a colossal aid package in Congress, and stocks fell again on Wall Street even after the Federal Reserve said it will lend to small and large businesses and local governments to help them through the crisis. The Dow Jones Industrial Average lost over 580 points, or 3 percent.

Warning that the outbreak continues to accelerate, the head of the World Health Organization called on countries to take strong, coordinated action.

“We are not helpless bystanders,” Tedros Adhanom Ghebreyesus said, noting that it took 67 days to reach 100,000 cases worldwide but just four days to go from 200,000 to 300,000. “We can change the trajectory of this pandemic.”

Britain joined other countries in ordering residents to restrict their movements, imposing its most draconian restrictions ever in peacetime.

The scramble to marshal public health and political resources intensified in New York, where a statewide lockdown took effect amid worries the city of 8.4 million is becoming one of the world’s biggest hot spots. More than 12,000 people have tested positive in the city and almost 100 have died.

The governor announced plans to convert a mammoth New York City convention center into a hospital with 1,000 beds. Meanwhile, the mayor warned that the city’s hospitals are just 10 days away from shortages in basic supplies needed to protect health care workers and patients alike.

“This is going to get much worse before it gets better. We are still in the relative calm before the storm,” Gov. Andrew Cuomo said at the Jacob K. Javits Convention Center.

In Italy, the hardest-hit country of all, declines in both new cases and deaths for a second consecutive day provided a faint glimmer of hope, though it is too soon to say whether the crisis is leveling off.

Italian officials said Monday that the virus had claimed just over 600 more lives, down from 793 two days earlier. All told, the outbreak has killed more than 6,000 Italians, the highest death toll of any country, and pushed the health system to the breaking point there and in Spain.

The risk to doctors, nurses and others on the front lines has become plain: Italy has seen at least 18 doctors with coronavirus die. Spain reported that more than 3,900 health care workers have become infected, accounting for roughly 12% of the country’s total cases.

British health workers pleaded for more gear, saying they felt like “cannon fodder.” In France, doctors scrounged masks from construction workers, factory floors, an architect.

“There’s a wild race to get surgical masks,” François Blanchecott, a biologist on the front lines of testing, told France Inter radio. “We’re asking mayors’ offices, industries, any enterprises that might have a store of masks.”

The way U.S. officials respond to the severe pressure on hospitals — and people’s willingness to keep their distance from others — will prove critical in coming days, public health experts said.

“Actions taken right now will have a huge impact on the course of this epidemic in the U.S.,” said Josh Michaud, associate director of global health policy with the Kaiser Family Foundation in Washington. “It’s an important moment.”

British Prime Minister Boris Johnson on Monday night directed residents to stay home, with a few exceptions, and ordered shops that don’t sell essential goods to shut down. He called it a critical step to prevent the virus from spreading and warned that police would be authorized to break up public gatherings of more than two people.

New infections are increasing at an exponential rate, raising concern that the United Kingdom will be on a trajectory like Italy’s in a week or two if containment efforts don’t work.

The crisis kept easing in China. The city of Wuhan, where the outbreak first emerged late last year, said it is allowing residents limited movement as its lockdown is gradually relaxed. China is now sending planeloads of protective gear and doctors to Europe.

“The U.S. is completely wasting the precious time that China has won for the world,” said Geng Shuang, the Chinese Foreign Ministry spokesman.

Dr. Anthony Fauci, the U.S. government’s top infectious-disease expert, promised that medical supplies are about to start pouring in and will be “clearly directed to those hot spots that need it most.”

On Capitol Hill, a nearly $2 trillion plan that would prop up businesses and send checks to American households has stalled. Democrats argued it was tilted toward corporations rather than workers and health care providers.

President Donald Trump suggested that the remedies to fight the epidemic might be more harmful than the outbreak itself and vowed to reassess government restrictions after the U.S. shutdown reaches the 15-day mark.

“WE CANNOT LET THE CURE BE WORSE THAN THE PROBLEM ITSELF,” he tweeted.

Democratic presidential candidate Joe Biden criticized Trump for not using the full force of federal authority to combat the virus.

“Trump keeps saying he’s a wartime president,” Biden said in an online address. “Well, start acting like one.”

Worldwide, more than 374,000 people have been infected and over 16,000 have died from the virus, according to a running tally kept by Johns Hopkins University. More than 1.5 billion people around the globe have been instructed to stay in their homes.

After just a few weeks, the U.S. has more than 42,800 cases and more than 500 deaths. Indiana, Michigan and West Virginia joined states including California, Illinois and New York in asking or ordering their residents to stay home and keep businesses closed — directives that now cover more than one-third of the U.S. population.

Industries big and small continued to shut down. Boeing announced it is suspending production in the Seattle area, where it has two mammoth aircraft plants employing about 42,000 people.

U.N. Secretary-General Antonio Guterres called for an immediate cease-fire in conflicts around the world to tackle the pandemic.

“It is time to put armed conflict on lockdown and focus together on the true fight of our lives,” he said.

Former Hollywood studio boss Harvey Weinstein tested positive at the prison in New York where he is serving a 23-year sentence for rape and sexual assault, the head of the guards union said. German Chancellor Angela Merkel tested negative after putting herself in quarantine, according to a spokesman. Minnesota Sen. Amy Klobuchar, the former presidential candidate, disclosed that her husband has been hospitalized with the virus.

For most people, the coronavirus causes only mild or moderate symptoms, such as fever or coughing. But for some older adults and people with existing health problems, it can cause more severe illness, including pneumonia. Over 100,000 people have recovered, mostly in China.

Authorities kept up their push to get people to stay home, but some were clearly not listening.

In New York, Cuomo fumed over gatherings of young people in violation of his order that everyone stay 6 feet (2 meters) apart, saying, “It’s reckless and it’s violative of your civic spirit and duty as a citizen, as far as I’m concerned.”

In a city where many people live in buildings with small elevators, a 21-story high-rise in the Chelsea neighborhood posted a notice in the lobby warning that there should be just one person per elevator, and those going to the laundry room shouldn’t use a washing machine next to another one in use.

“People are really only going to get food and going back. That’s what we need,” said Matt Comet, making a brief dash into the nearly empty streets of his Manhattan neighborhood to pick up a carryout meal.

“I’m OK to have a book and watch TV for a bit, but if it continues for another month, another two months, it’ll be pretty crazy,” he said.

India took the extraordinary step of shutting down the nation’s vast rail system, the lifeblood of the country of 1.3 billion people.

Japanese Prime Minister Shinzo Abe acknowledged that postponing this year’s Summer Olympics in Tokyo could be unavoidable. The International Olympic Committee said it will examine the situation over the next few weeks.