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Los Angeles County has the highest COVID-19 infection rates in California; see where every other region lands

Merline Jimenez (L) administers a COVID-19 nasopharyngeal swab to a person at a testing site located in the international terminal at Los Angeles International Airport amid a surge in omicron variant cases on Dec. 21, 2021. (Mario Tama/Getty Images)

The vaccine deployment in December 2020 signaled a turning point in the COVID-19 pandemic. By the end of May 2021, 40% of the U.S. population was fully vaccinated. But as vaccination rates lagged over the summer, new surges of COVID-19 came, including delta in the summer of 2021, and now the omicron variant, which comprises the majority of cases in the U.S.

Researchers around the world have reported that omicron is more transmissible than delta, making breakthrough and repeat infections more likely. Early research suggests this strain may cause less severe illness than Delta and the original virus, however, health officials have warned an Omicron-driven surge could still increase hospitalization and death rates—especially in areas with less vaccinated populations.


The United States as of Jan. 4 reached 828,344 COVID-19-related deaths and nearly 56.5 million COVID-19 cases, according to Johns Hopkins University. Currently, 62% of the population is fully vaccinated, and 33.4% have received booster doses.

Stacker compiled a list of the counties with highest COVID-19 infection rates in California using data from the U.S. Department of Health & Human Services, with Los Angeles County landing at the top. Counties are ranked by the highest infection rate per 100,000 residents within the week leading up to Jan. 3, 2021. Cumulative cases per 100,000 served as a tiebreaker.

Keep reading to see whether your county ranks among the highest COVID-19 infection rates in your state.

50. Colusa County

49. Shasta County

48. Mendocino County

47. Sierra County

46. Tehama County

45. Amador County

44. Nevada County

43. Calaveras County

42. Del Norte County

41. Madera County

40. Monterey County

39. Yuba County

38. Fresno County

37. Stanislaus County

36. Tulare County

35. Kings County

34. Merced County

33. Butte County

32. Sutter County

31. Tuolumne County

30. Glenn County

29. El Dorado County

28. Humboldt County

27. Mariposa County

26. Placer County

25. San Joaquin County

24. Santa Cruz County

23. Solano County

22. Sacramento County

21. Yolo County

20. Sonoma County

19. Alameda County

18. San Luis Obispo County

17. Contra Costa County

16. Santa Barbara County

15. Orange County

14. Napa County

13. San Bernardino County

12. Inyo County

11. Riverside County

10. San Mateo County

9. San Benito County

8. Imperial County

7. Ventura County

6. Marin County

5. San Diego County, CA

4. Mono County

3. Santa Clara County

2. San Francisco County

1. Los Angeles County